New Pfizer antiviral and ivermectin, a pharmacodynamic analysis New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄ PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease, https://www.pfizer.com/news/press-rel… So, what is a protease? So what is a protease inhibitor? And, what is 3CL? Chymotrypsin-like protease (3CL main protease, or 3CL Mpro) Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020) https://pubs.acs.org/doi/abs/10.1021/… The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection https://pubs.rsc.org/en/content/artic… the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket: Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents https://www.nature.com/articles/s4200… as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration. Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly. Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study https://pubs.rsc.org/en/content/artic… From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1 https://bnf.nice.org.uk/medicinal-for… Ritonavir, C37H48N6O5S2 Ivermectin, C48H74O14 Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach https://www.ncbi.nlm.nih.gov/pmc/arti… We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6. PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease, https://www.pfizer.com/news/press-rel… Risk of virus developing resistance to PF-07321332 Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2 https://www.frontiersin.org/articles/… With SARS-CoV-2 S Spike protein Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2. In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein) The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions Binding Interactions of Selected Drugs With Human ACE-2 Protein that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions With SARS-CoV-2 S Glycoprotein Ivermectin showed the highest binding affinity to the predicted active site of the protein With SARS-CoV-2 Nsp14 Protein ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions.
German 7-day COVID19 incidence sets third record in a row….. Russia: New record in daily coronavirus fatalities…..Hungary adds most daily virus cases in 7 months.. Ukraine breaks another record for the number of daily deaths from coronavirus……. China reports 89 COVID cases as outbreaks grow……… COVID cases spike in Greece, hospitals buckle….bark Bark BARK!!
The German seven-day COVID-19 incidence rate continues to increase since setting a record and rising above 200 for the first time on Monday. Early on Wednesday, data compiled by the Robert Koch Institute (RKI) showed that the rate, which measures the number of people infected per 100,000, has risen to 232.1 to reach its highest level since the pandemic began. The nationwide death toll increased to 96,963 in the meantime, with another 236 fatal outcomes attributed to the virus, while the total number of infections rose by 39,676 to 4,844,054.
Continue reading “German 7-day COVID19 incidence sets third record in a row….. Russia: New record in daily coronavirus fatalities…..Hungary adds most daily virus cases in 7 months.. Ukraine breaks another record for the number of daily deaths from coronavirus……. China reports 89 COVID cases as outbreaks grow……… COVID cases spike in Greece, hospitals buckle….bark Bark BARK!!”
France extends COVID-19 booster shots, requires them for health pass
COVID-19 hospitalizations rising in parts of California, a potentially ominous sign…. BARK BARK BARK
COVID-19 hospitalizations have risen significantly in the Inland Empire and Central Valley, bringing new concerns about whether the shift represents a precursor to a wider spike in COVID-19 in California as the winter holidays approach. Across the state, both cases and hospitalizations hit a plateau after months of decline. Hospitalizations have remained fairly flat in some areas with relatively high vaccination rates, including the San Francisco Bay Area and Los Angeles County. But in some areas with lower vaccination rates, such as Riverside, San Bernardino and Fresno counties, conditions are deteriorating, with hospitalizations up by more than 20% in recent weeks. And even some places with relatively high vaccination rates are seeing COVID-19 hospitalizations tick upward; in Orange County, COVID-19 hospitalizations are up by 16% since Halloween.
Health officials have been warning about a potential new rise in COVID-19 in California as seniors who got their shots last winter — and haven’t received a booster shot — may start to see their immunity wane, leaving them exposed to greater risk for infection and hospitalization, and as people gather indoors more as the weather cools and the holidays approach. Continue reading “COVID-19 hospitalizations rising in parts of California, a potentially ominous sign…. BARK BARK BARK”
German coronavirus infection rate hits highest since pandemic began… Russia’s COVID death toll up by record 1,211… Dutch hospitals urge new measures as COVID-19 cases near record… BARK BARK BARK
Germany’s coronavirus infection rate has risen to its highest level since the start of the pandemic, public health figures showed on Monday, and doctors warned they will need to postpone scheduled operations in coming weeks to cope. The seven-day incidence rate – the number of people per 100,000 to be infected over the last week – rose to 201.1, higher than a previous record of 197.6 in December last year, the figures from the Robert Koch Institute showed on Monday. The number of confirmed coronavirus cases rose to 4,782,546 from 4,767,033 a day earlier. The number of deaths increased by 33 to a total of 96,558. Bavaria state premier Markus Soeder called for more decisive action in view of the new peak in the incidence rate. More needs to be done “than a little compulsory testing in old people’s homes”, he told Deutschlandfunk radio. He called for tests to be offered free of charge again, vaccination centres to be reactivated and for states and the federal government to coordinate their strategies. Germany has abolished free testing to incentivise people to get shots. Christian Karagiannidis, scientific director at the DIVI association for intensive and emergency medicine, said an expected rise in coronavirus cases in coming weeks meant some scheduled operations would have to be postponed. “We will only be able to cope with the burden of all emergencies if savings are made somewhere else, though definitely not with surgical cancer treatments,” he told the Augsburger Allgemeine newspaper. Germany has already had to relocate some patients from regions with overburdened hospitals. The three German parties working to agree on a coalition government by early December will present proposals to combat a fourth wave of the COVID-19 pandemic in the country on Monday, daily newspaper Die Welt said. Continue reading “German coronavirus infection rate hits highest since pandemic began… Russia’s COVID death toll up by record 1,211… Dutch hospitals urge new measures as COVID-19 cases near record… BARK BARK BARK”
Five Mutations Present in Delta Plus COVID-19 Variant…
Structural changes to the COVID-19 virus highlight the need to expand the research efforts.
Five specific mutations are more prevalent in the Delta Plus variant of COVID-19 compared to the Delta variant, according to the results of a new study published in the Journal of Autoimmunity. “Whether it is natural antibodies produced from previously having COVID-19 or the antibodies produced from the vaccine, we are showing structurally how dangerous and clever the virus is by being able to mutate in a way that the antibodies don’t seem to recognize and defend against these new variants,” Austin Spratt, an undergraduate student at University of Missouri (MU), said in a press release.
Continue reading “Five Mutations Present in Delta Plus COVID-19 Variant…”
China Tells Citizens to Stockpile Food….. China food supply: How a warning sparked panic buying ……..Bark Bark Bark
“China has warned families to store food and other essentials in case of emergencies, as officials drastically tighten restrictions to control a small Covid-19 outbreak,” the Financial Times reports. “Beijing’s already harsh ‘zero Covid’ policies have grown even stricter as coronavirus cases climb in the country despite targeted lockdowns.” Continue reading “China Tells Citizens to Stockpile Food….. China food supply: How a warning sparked panic buying ……..Bark Bark Bark”
Europe faces growing COVID-19 resurgence despite vaccination progress…… BARK BARK BARK
Infections in Europe are returning to high levels as winter takes hold – prompting debate on whether curbs will need to be introduced in the lead-up to Christmas. Dr Edward Kelly. a former Director of Integrated Health Services at the WHO, says the success of vaccination programs means many people believe the threat of COVID is gone, and are no longer practicing the basic public health measures needed to keep the virus under control. NN: Warning prepare yourself for the triple wammie jammiee.
- wammie number one is run away embedded inflation
- wammie number two is the self inflected wound of a TEMPORARY energy crises
- wammie number three is the new covid19 mutation starting a new death assault on mankind….. and China did it again.
Yes i know 2 things. Dark clouds are forming and i know what they are and where they are from. .And yes i know what to do to keep you health, wealthy and wise,,,, its my job as your in house librarian. And i love my job and thank you for the work…
Global COVID-19 cases hit 250 million, eastern Europe infections at record levels
Nov 8 (Reuters) – Global COVID-19 cases surpassed 250 million on Monday as some countries in eastern Europe experience record outbreaks, even as the Delta variant surge eases and many countries resume trade and tourism. The daily average number of cases has fallen by 36% over the past three months, according to a Reuters analysis, but the virus is still infecting 50 million people every 90 days due to the highly transmissible Delta variant. By contrast, it took nearly a year to record the first 50 million COVID-19 cases. Health experts are optimistic that many nations have put the worst of the pandemic behind them thanks to vaccines and natural exposure, although they caution that colder weather and upcoming holiday gatherings could increase cases. “We think between now and the end of 2022, this is the point where we get control over this virus … where we can significantly reduce severe disease and death,” Maria Van Kerkhove, an epidemiologist leading the World Health Organisation, told Reuters on Nov. 3. Continue reading “Global COVID-19 cases hit 250 million, eastern Europe infections at record levels”
UK reports 30,305 new COVID-19 cases on Sunday, 62 deaths…. Merck’s COVID drug to be rolled out this month in UK
LONDON, Nov 7 (Reuters) – Britain reported 62 deaths on Sunday of people who had tested positive for COVID-19 within the past 28 days, and a further 30,305 new infections. The government figures show a fall from the 155 deaths and 30,693 new cases reported on Saturday. Continue reading “UK reports 30,305 new COVID-19 cases on Sunday, 62 deaths…. Merck’s COVID drug to be rolled out this month in UK”